Chicken IL12B Rabbit polyclonal antibody

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SKU:: A25100
Zusätzliche Namen:: IL-12B|IL-12p40
Anwendung:: ELISA, WB
Molekulargewicht:: 45kDa
Spezies-Reaktivität:: Avian
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Spezies:: Avian
Sequenz:: QWKLRENVYVIESEWNDETPAKKVKLTCDTSDEALPVYWKKGTELKGTGKTLTTEVKEFPDAGNYTCLSAKTHEIISYSFFLITKVDSNGQMIRSILKSYKEPSKTFLKCEAKNYSGIFTCSWMTENESPSVKFTIRSLKGSQGDVTCSSPVARTDKSVTEYTAQCQKENYCPFAEEHQPTEMFLEVIDEVEYENYTSSFFIRDIIKPDPPQCQYASTNGTVTWTYPKTWSTPKSYFPLTFRVKVESTKKYKSKVYDADEQSIQIPKTGPKDKISVQARDRYYNSSWSEWSTLCR
Uniprot:: Q6X0K9
Synonyme:: Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 p40 subunit;IL-12 subunit p40;IL-12B;IL-12p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 beta chain;interleukin-12 p40 subunit;interleukin-12 subunit beta;interleukin-12p40
Weitere Details:: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Versandbedingungen:: Blue Ice