A25046
Ikaros Rabbit polyclonal antibody
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£152.00
- SKU:
- A25046
- Zusätzliche Namen:
- CVID13|Hs.54452|IK1|IKAROS|LyF-1|LYF1|PPP1R92|PRO0758|ZNFN1A1
- Anwendung:
- ELISA, WB
- Molekulargewicht:
- 50-70kDa
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulierung:
- Unmodified
- Sequenz:
- SASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGE
- Uniprot:
- Q13422
- Synonyme:
- CLL-associated antigen KW-6;CVID13;DNA-binding protein Ikaros;Hs.54452;IK1;IKAROS;ikaros family zinc finger protein 1;LyF-1;LYF1;lymphoid transcription factor LyF-1;PPP1R92;PRO0758;protein phosphatase 1, regulatory subunit 92;zinc finger protein, subfamily 1A, 1 (Ikaros);ZNFN1A1
- Weitere Details:
- This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
- Versandbedingungen:
- Blue Ice