Vinculin Rabbit monoclonal antibody

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SKU:: A23468
Zusätzliche Namen:: CMD1W|CMH15|HEL114|MV|MVCL|Vinculin
Anwendung:: ELISA, WB, IHC-P
Molekulargewicht:: 124kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: EMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQ
Uniprot:: P18206
Synonyme:: CMD1W;CMH15;epididymis luminal protein 114;epididymis secretory sperm binding protein;HEL114;meta-vinculin;metavinculin;MV;MVCL;vinculin;vinculin isoform meta-VCL
Weitere Details:: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.