pan-Trk Rabbit polyclonal antibody

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£152.00

SKU:: A22121
Anwendung:: ELISA, WB
Molekulargewicht:: 120-140kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Mouse
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Sequenz:: ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Uniprot:: P04629, Q16288, Q16620
Synonyme:: BDNF-tropomyosine receptor kinase B;BDNF/NT-3 growth factors receptor;DEE58;EIEE58;ETS related protein-neurotrophic receptor tyrosine kinase fusion protein;ETV6-NTRK3 fusion;gp140trk;GP145-TrkB;GP145-TrkC;gp145(trkC);high affinity nerve growth factor receptor;MTC;Neurotrophic tyrosine kinase receptor type 1;neurotrophic tyrosine kinase receptor type 2;Neurotrophic tyrosine kinase receptor type 3;neurotrophic tyrosine kinase, receptor, type 1;neurotrophic tyrosine kinase, receptor, type 3;NT-3 growth factor receptor;OBHD;Oncogene TRK;p140-TrkA;TRK;Trk-A;trk-B;TRK1;TRK1-transforming tyrosine kinase protein;TRKA;TRKB;TrkB tyrosine kinase;TRKC;TrkC tyrosine kinase;tropomyosin-related kinase A;tropomyosin-related kinase B;Tyrosine kinase receptor;tyrosine kinase receptor A;tyrosine kinase receptor B;tyrosine kinase receptor C
Weitere Details:: Neurotrophic tyrosine kinase (NTRK) is a family of receptor tyrosine kinase.The NTRK gene family contains three members, NTRK1, NTRK2 and NTRK3, which produce TRKA, TRKB and TRKC proteins, respectively.TRK kinases leads to cell differentiation and may play important roles in normal neural functions.Rearrangements in the NTRK genes can result in two genes fusing together and producing altered TRK proteins, which can lead to uncontrolled growth of cancer cells. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer.

Versandbedingungen:: Blue Ice