A22073
APC Rabbit monoclonal antibody
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- SKU:
- A22073
- Zusätzliche Namen:
- APC|BTPS2|DESMD|DP2|DP2.5|DP3|GS|PPP1R46
- Anwendung:
- ELISA, WB, IHC-P, IF
- Molekulargewicht:
- 160kDa
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulierung:
- Unmodified
- Sequenz:
- QSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERT
- Uniprot:
- P25054
- Synonyme:
- adenomatosis polyposis coli tumor suppressor;adenomatous polyposis coli (APC);adenomatous polyposis coli protein;APC, WNT signaling pathway regulator;BTPS2;deleted in polyposis 2.5;DESMD;DP2;DP2.5;DP3;epididymis secretory sperm binding protein;GS;PPP1R46;protein phosphatase 1, regulatory subunit 46;truncated adenomatosis polyposis coli;WNT signaling pathway regulator
- Weitere Details:
- This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
- Versandbedingungen:
- Blue Ice