[KO Validated] MSH6 Rabbit polyclonal antibody

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£152.00

SKU:: A21445
Zusätzliche Namen:: GTBP|GTMBP|HNPCC5|HSAP|LYNCH5|MMRCS3|MSH-6|MSH6|p160
Anwendung:: ELISA, WB, IHC-P, IF, ICC
Molekulargewicht:: 160kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKM
Uniprot:: P52701
Synonyme:: DNA mismatch repair protein Msh6;G/T mismatch-binding protein;GTBP;GTMBP;HNPCC5;HSAP;MMRCS3;mutS protein homolog 6;mutS-alpha 160 kDa subunit;p160;sperm-associated protein
Weitere Details:: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Versandbedingungen:: Blue Ice