TrkA Rabbit polyclonal antibody

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£152.00

SKU:: A2098
Zusätzliche Namen:: MTC|p140-TrkA|TRK|Trk-A|TRK1|TRKA
Anwendung:: ELISA, WB, IHC-P
Molekulargewicht:: 120kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Uniprot:: P04629
Synonyme:: gp140trk;high affinity nerve growth factor receptor;MTC;Neurotrophic tyrosine kinase receptor type 1;neurotrophic tyrosine kinase, receptor, type 1;Oncogene TRK;p140-TrkA;TRK;Trk-A;TRK1;TRK1-transforming tyrosine kinase protein;TRKA;tropomyosin-related kinase A;Tyrosine kinase receptor;tyrosine kinase receptor A
Weitere Details:: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.