A16374
FGD1 Rabbit polyclonal antibody
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£152.00
- SKU:
- A16374
- Zusätzliche Namen:
- AAS|FGD1|FGDY|MRXS16|ZFYVE3
- Anwendung:
- ELISA, WB, IHC-P, IF, ICC
- Molekulargewicht:
- 110kDa
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C 50% glycerol. Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulierung:
- Unmodified
- Sequenz:
- LLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACS
- Uniprot:
- P98174
- Synonyme:
- AAS;faciogenital dysplasia 1 protein;FGDY;FYVE, RhoGEF and PH domain-containing protein 1;MRXS16;rho/Rac GEF;rho/Rac guanine nucleotide exchange factor FGD1;ZFYVE3;zinc finger FYVE domain-containing protein 3
- Weitere Details:
- This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability.
- Versandbedingungen:
- Blue Ice