PDP1 Rabbit polyclonal antibody

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£152.00

SKU:: A14545
Zusätzliche Namen:: PDH|PDP|PDP1|PDPC|PPM2A|PPM2C
Anwendung:: ELISA, WB, IF, ICC
Molekulargewicht:: 61kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C 50% glycerol. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: ASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFL
Uniprot:: Q9P0J1
Synonyme:: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial;PDH;PDP;PDP 1;PDPC;PDPC 1;PPM2A;PPM2C;Protein phosphatase 2C;protein phosphatase 2C, magnesium-dependent, catalytic subunit;protein phosphatase, Mg2+/Mn2+ dependent 2A;pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase;Pyruvate dehydrogenase phosphatase catalytic subunit 1;pyruvate dehyrogenase phosphatase catalytic subunit 1
Weitere Details:: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Versandbedingungen:: Blue Ice