RUNX2 Rabbit monoclonal antibody

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SKU:: A11753
Zusätzliche Namen:: AML3|CBF-alpha-1|CBFA1|CCD|CCD1|CLCD|OSF-2|OSF2|PEA2aA|PEBP2aA|RUNX2
Anwendung:: ELISA, WB, IP
Molekulargewicht:: 60kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: PRRISDDDTATSDFCLWPSTLSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQT
Uniprot:: Q13950
Synonyme:: acute myeloid leukemia 3 protein;AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;Core-binding factor subunit alpha-1;core-binding factor, runt domain, alpha subunit 1;oncogene AML-3;OSF-2;OSF2;osteoblast-specific transcription factor 2;PEA2-alpha A;PEA2aA;PEBP2-alpha A;PEBP2aA;polyomavirus enhancer-binding protein 2 alpha A subunit;runt related transcription factor 2;runt-related transcription factor 2;SL3-3 enhancer factor 1 alpha A subunit;SL3/AKV core-binding factor alpha A subunit
Weitere Details:: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Versandbedingungen:: Blue Ice