Alpha Synuclein pSer129 Pre-Formed Fibrils
Produktgrößen
100 ug
£1112,00
SPR-521-100UG
2 x 100 ug
£1705,00
SPR-521-2X100UG
500 ug
£3385,00
SPR-521-500UG
Über dieses Produkt
- SKU:
- SPR-521
- Zusätzliche Namen:
- Alpha-synuclein, Alpha synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, SYN, PD1, PARK4, Synuclein Alpha, Alpha Synuclein pSer129, Asyn, Alpha Synuclein PFFs
- Anwendung:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Weitere Details:
- Alpha-synuclein (A Alpha-synuclein), a neuronal protein encoded by the SNCA gene, plays a central role in synaptic vesicle trafficking and neurotransmitter release. In neurodegenerative diseases such as Parkinson's disease, A Alpha-synuclein aggregates into fibrillar structures, with phosphorylation at serine 129 (pSer129) being the most prevalent post-translational modification observed in pathological inclusions like Lewy bodies. Pre-formed fibrils (PFFs) composed of A Alpha-synuclein phosphorylated at Ser129 replicate key features of disease-associated aggregates. These pSer129 PFFs exhibit enhanced seeding capacity and altered structural properties, making them highly effective in inducing endogenous A Alpha-synuclein aggregation in cellular and animal models. Their ability to mimic disease-relevant pathology-including fibril morphology, neurotoxicity, and prion-like propagation-makes them indispensable tools for mechanistic studies. In neurodegenerative disease research, pSer129 PFFs enable detailed investigation into the role of phosphorylation in modulating A Alpha-synuclein aggregation, intercellular transmission, and neuroinflammatory responses. They are also used to evaluate therapeutic strategies targeting phosphorylation-dependent aggregation pathways, promoting clearance of toxic species, and restoring neuronal function. By modeling the biochemical and pathological characteristics of A Alpha-synuclein aggregates, pSer129 PFFs accelerate translational research and drug development for Parkinson's disease and related synucleinopathies. StressMarq's Alpha Synuclein Ser129 Pre-Formed Fibrils are generated in-vitro from purified phosphorylated monomer and phosphorylation is confirmed with our anti-ASYN pS129 monoclonal antibody (catalog# SMC-600).
- Immunogen:
- Alpha Synuclein pSer129 PFFs
- Molekulargewicht:
- 14.46 kDa
- Reinheit:
- >95%
- Aufreinigung:
- Ion Exchange
- Sequenz:
- MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- -70[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/alpha-synuclein-pser129-pre-formed-fibrils-spr-521/