Alpha Synuclein Monomers
Produktgrößen
100 ug
£573,00
SPR-481-100UG
2 x 100 ug
£842,00
SPR-481-2X100UG
5 x 100 ug
£1582,00
SPR-481-5X100UG
Über dieses Produkt
- SKU:
- SPR-481
- Zusätzliche Namen:
- Alpha-synuclein, Alpha synuclein, Asyn, SNCA, NACP, PARK1, PARK4, PD1, Synuclein alpha, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Synuclein Alpha-140, SYN, Parkinson's disease familial 1 Protein Protein
- Anwendung:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Konzentration:
- 2 mg/ml
- Weitere Details:
- Alpha-synuclein is a neuronal protein that plays a central role in synaptic vesicle trafficking, neurotransmitter release, and dopamine regulation. In its native monomeric form, alpha-synuclein contributes to normal neuronal function by enhancing vesicle priming and fusion, and by acting as a molecular chaperone for SNARE complex assembly. In neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, alpha-synuclein undergoes pathological misfolding and aggregation. While oligomers and fibrils are widely studied for their neurotoxicity, monomeric alpha-synuclein is increasingly recognized as a critical starting point for understanding disease initiation. Subtle conformational changes in monomers-triggered by mutations, post-translational modifications, or environmental stress-can prime the protein for aggregation and disrupt its physiological roles. Alpha-synuclein monomers are essential tools in mechanistic studies aimed at identifying early biomarkers and therapeutic targets. Their use in biochemical and cellular models enables high-resolution analysis of folding dynamics, membrane interactions, and protein-protein associations. These insights inform strategies to stabilize native alpha-synuclein and prevent its pathological transformation.
- Immunogen:
- Alpha Synuclein Monomers
- Molekulargewicht:
- 14.515 kDa
- Reinheit:
- >95%
- Aufreinigung:
- Ion Exchange
- Sequenz:
- MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTK EQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDP SSEAYEMPSEEGYQDYEPEA
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- -70[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/alpha-synuclein-protein-spr-481/