Alpha Synuclein Oligomers (Dopamine HCL Stabilized)
Produktgrößen
100 ug
£849,00
SPR-466-100UG
2 x 100 ug
£1286,00
SPR-466-2X100UG
5 x 100 ug
£2474,00
SPR-466-5X100UG
Über dieses Produkt
- SKU:
- SPR-466
- Zusätzliche Namen:
- Alpha-synuclein, Alpha synuclein, Asyn, SNCA, NACP, PARK1, PARK4, PD1, Synuclein alpha, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Synuclein Alpha-140, SYN, Parkinson's disease familial 1 Protein Protein
- Anwendung:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Konzentration:
- 2 mg/ml
- Weitere Details:
- Alpha-synuclein, encoded by the SNCA gene (UniProt ID: P37840), is a neuronal protein involved in synaptic vesicle trafficking and neurotransmitter release. While normally functioning as a monomer, under pathological conditions alpha-synuclein misfolds and assembles into soluble oligomers-intermediates in the formation of insoluble fibrils found in Lewy bodies, the hallmark of Parkinson's disease and related synucleinopathies. Alpha-synuclein oligomers are increasingly recognized as the most neurotoxic species in the aggregation pathway. These conformers disrupt cellular homeostasis by impairing membrane integrity, mitochondrial function, and proteasomal degradation. Their ability to propagate between cells in a prion-like manner contributes to the progressive spread of pathology across brain regions. Experimental models using alpha-synuclein oligomers have revealed their role in triggering neuroinflammation, synaptic dysfunction, and dopaminergic neuron loss. These insights have positioned oligomers as critical targets for therapeutic intervention and biomarker development. Due to their structural and functional relevance to human disease, alpha-synuclein oligomers are widely used in preclinical research to evaluate aggregation inhibitors, immunotherapies, and neuroprotective agents. Their application enhances the translational potential of drug discovery efforts aimed at halting or reversing neurodegenerative progression.
- Immunogen:
- Alpha Synuclein Oligomers
- Molekulargewicht:
- ~14.46 kDa
- Reinheit:
- >95%
- Aufreinigung:
- Ion Exchange
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- -70[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Epitope Tag:
- Untagged
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/alpha-synuclein-protein-spr-466/