Amyloid Beta 1-42 Oligomers
Produktgrößen
100 ug
£849,00
SPR-488-100UG
2 x 100 ug
£1286,00
SPR-488-2X100UG
5 x 100 ug
£2474,00
SPR-488-5X100UG
Über dieses Produkt
- SKU:
- SPR-488
- Zusätzliche Namen:
- AB Beta 1-42, Amyloid beta, Beta amyloid peptide, Abeta, Abeta peptide, Amyloid beta precursor peptide, APP, Beta-APP42, Abeta42, A4, ABPP, APPI, Alzheimer disease amyloid A4, Alzheimer disease amyloid, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, PN-II
- Anwendung:
- Cell-based/Functional Assay, Western Blot
- Buffer:
- Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
- CE/IVD:
- RUO
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Amyloid beta (AB Beta) peptides, particularly the 42-residue variant AB Beta 1-42, are central to the pathogenesis of Alzheimer's disease. While fibrillar aggregates form the hallmark amyloid plaques, it is the soluble oligomeric intermediates of AB Beta 1-42 that are increasingly recognized as the most neurotoxic species. AB Beta 1-42 oligomers disrupt neuronal function by impairing synaptic transmission, altering calcium homeostasis, and triggering oxidative stress and inflammation. These small aggregates interact with cell membranes, receptors, and intracellular signaling pathways, leading to progressive neurodegeneration. Their ability to seed further aggregation and propagate pathology across brain regions mirrors prion-like mechanisms observed in other proteinopathies. In research settings, AB Beta 1-42 oligomers serve as a critical model for studying early-stage Alzheimer's disease. They enable high-resolution analysis of misfolding kinetics, neurotoxicity, and cellular responses. Their relevance to human pathology makes them ideal for evaluating therapeutic strategies aimed at neutralizing oligomeric species, preventing aggregation, and restoring neuronal health. By capturing the transition from monomeric peptide to pathogenic aggregate, AB Beta 1-42 oligomers provide a powerful platform for advancing biomarker discovery and the development of disease-modifying treatments in neurodegenerative research. StressMarq's Amyloid Beta 1-42 (AB Beta42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). StressMarq's AB Beta42 oligomers present as globular oligomers when observed under TEM and AFM, have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody, and exhibited dose-dependent toxicity in primary rat cortical neurons.
- Immunogen:
- Amyloid Beta Oligomers
- Molekulargewicht:
- 4.5 kDa
- Reinheit:
- >95%
- Sequenz:
- DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- -70[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Synthetic
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/amyloid-beta-protein-spr-488/