HSP70 Protein
Produktgrößen
50 ug
£376,00
SPR-108-50UG
100 ug
£495,00
SPR-108-100UG
Über dieses Produkt
- SKU:
- SPR-108
- Zusätzliche Namen:
- HSPA1A, HSPA1B, HSPA1, HSP70, HSP70-1, HSP70.1, HSP70-2, HSP72, HSP73, HSX70, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B
- Anwendung:
- Cell-based/Functional Assay, ELISA, SDS-PAGE, Western Blot
- Buffer:
- 50mM Tris/HCl pH7.5, 2.5mM Bme, 0.15M NaCl, 10% glycerol
- CE/IVD:
- RUO
- Weitere Details:
- HSP70 is a highly inducible molecular chaperone that plays a pivotal role in protein quality control across all major cellular compartments. In the brain, HSP70 is essential for preventing the aggregation of misfolded proteins, a key pathological feature of neurodegenerative diseases. HSP70 binds to nascent and partially folded polypeptides, stabilizing them and facilitating proper folding or directing them toward degradation pathways. This function is particularly critical in conditions such as Alzheimer's, Parkinson's, and ALS, where protein aggregation and impaired proteostasis drive neuronal dysfunction and cell death. The chaperone activity of HSP70 is regulated by ATP binding and hydrolysis, which triggers conformational changes that control substrate binding and release. Its ability to recognize hydrophobic regions of unfolded proteins enables it to suppress aggregation and promote cellular recovery from stress. Therapeutic strategies aimed at enhancing HSP70 expression or activity are under investigation for their potential to reduce neurotoxicity, improve protein clearance, and slow disease progression in neurodegenerative disorders.
- Immunogen:
- HSP70 Protein
- Molekulargewicht:
- ~70 kDa
- Reinheit:
- >90%
- Aufreinigung:
- Multi-step Purified
- Sequenz:
- MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/hsp70-protein-spr-108/