HSC70 Protein
Produktgrößen
50 ug
£291,00
SPR-106-50UG
100 ug
£389,00
SPR-106-100UG
Über dieses Produkt
- SKU:
- SPR-106
- Zusätzliche Namen:
- Constitutive heat shock 70, HSC54, HSC71, HSC73, HSP71, HSP74, HSPA10, HSPA8, LAP1, NIP71
- Anwendung:
- Cell-based/Functional Assay, ELISA, SDS-PAGE, Western Blot
- Buffer:
- 50mM Tris/HCl, pH8, 0.3M NaCl
- CE/IVD:
- RUO
- Weitere Details:
- HSC70 (Heat Shock Cognate 70) is a constitutively expressed member of the HSP70 family, functioning as a molecular chaperone involved in protein folding, trafficking, and degradation. Unlike its inducible counterpart HSP70, HSC70 is present under normal physiological conditions and plays a continuous role in maintaining proteostasis. In the nervous system, HSC70 is essential for synaptic function, axonal transport, and the clearance of misfolded proteins. It is particularly relevant in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, where protein aggregation and impaired degradation pathways are central to disease progression. HSC70 binds to nascent and partially unfolded proteins, preventing aggregation and facilitating proper folding. It also participates in chaperone-mediated autophagy (CMA), a selective degradation pathway critical for removing damaged or misfolded proteins in neurons. Dysregulation of HSC70 or CMA has been linked to the accumulation of neurotoxic proteins and neuronal dysfunction. Its ATP-dependent conformational changes and interactions with co-chaperones enable HSC70 to adapt to cellular stress and support recovery. As a result, HSC70 is a promising target for therapeutic strategies aimed at enhancing protein clearance and restoring neuronal health in neurodegenerative conditions.
- Immunogen:
- HSC70 Protein
- Molekulargewicht:
- ~70 kDa
- Reinheit:
- >90%
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:https://www.stressmarq.com/products/protein/hsc70-protein-spr-106/