Alpha Synuclein Antibody
Produktgrößen
12 ug
£111,00
SPC-800-12UG
100 ug
£447,00
SPC-800-100UG
Über dieses Produkt
- SKU:
- SPC-800
- Zusätzliche Namen:
- Alpha Synuclein, A Alpha-Synuclein, SNCA, Snca, SYN, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease familial 1, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS pH 7.4, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Alpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is highly concentrated at presynaptic nerve terminals, suggesting a key role in synaptic transmission and plasticity (1). In addition to its synaptic localization, alpha-synuclein is abundantly expressed in mitochondria-rich brain regions, including the olfactory bulb, hippocampus, striatum, and thalamus, implicating it in mitochondrial function and energy metabolism (2). Functionally, alpha-synuclein has been shown to interact significantly with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. This interaction may be critical for maintaining neuronal structure and function, particularly in long-range axonal projections. Importantly, alpha-synuclein is essential for normal cognitive development. Genetic or functional inactivation of SNCA has been associated with impairments in spatial learning and working memory, underscoring its role in higher-order brain functions (4). Given its physiological importance and pathological aggregation in disorders such as Parkinson's disease and dementia with Lewy bodies, alpha-synuclein remains a focal point in neurodegenerative disease research. Understanding its normal function and mechanisms of misfolding is vital for developing targeted diagnostics and therapeutics.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human alpha Synuclein Fibril
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~14.46kda.
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:https://www.stressmarq.com/products/antibodies/polyclonal-antibodies/alpha-synuclein-antibody-spc-800/