ATG9B Antibody: ATTO 488
Produktgrößen
100 ug
£511,00
SPC-646D-A488-100UG
Über dieses Produkt
- SKU:
- SPC-646D-A488
- Zusätzliche Namen:
- ATG9B, ATG9B_HUMAN, APG9L2, APG9-like 2, Autophagy-related protein 9B, Protein sONE, NOS3AS, Nitric oxide synthase 3-overlapping antisense gene protein
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Klonalität:
- Polyclonal
- Konjugat:
- ATTO 488
- Konzentration:
- 1 mg/ml
- Weitere Details:
- ATG9B is a transmembrane protein essential for autophagy, a cellular degradation pathway critical for maintaining neuronal health. It plays a central role in the formation of cytoplasm-to-vacuole transport (Cvt) vesicles and the organization of the preautophagosomal structure (PAS), the nucleation site for autophagosome biogenesis. By regulating membrane trafficking to the phagophore assembly site, ATG9B ensures the proper initiation and progression of autophagy. In the context of neuroscience, ATG9B is gaining attention for its potential role in neurodegenerative disease mechanisms. Autophagy dysfunction is a hallmark of disorders such as Alzheimer's, Parkinson's, and Huntington's disease, where impaired clearance of protein aggregates and damaged organelles contributes to neuronal loss. ATG9B's involvement in early autophagosome formation positions it as a critical factor in maintaining neuronal proteostasis and synaptic integrity. Although ATG9B is highly expressed in the placenta and pituitary gland, its functional relevance in the central nervous system is increasingly recognized. Emerging studies suggest that modulating ATG9B activity could enhance autophagic flux and mitigate neurodegenerative pathology. Given its upstream role in autophagy and potential impact on neuronal survival, ATG9B represents a promising target for therapeutic intervention in neurodegenerative diseases. Ongoing research aims to elucidate its regulatory mechanisms and interactions within neural tissue.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from the N-terminal of Human ATG9B (aa. 110-121)
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~100 kDa.
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Polyclonal Antibody