Beclin 1 Antibody: ATTO 594
Produktgrößen
100 ug
£511,00
SPC-601D-A594-100UG
Über dieses Produkt
- SKU:
- SPC-601D-A594
- Zusätzliche Namen:
- Beclin 1, BECN1, BECN1_HUMAN, APG6, BCL-2 interacting protein beclin, Beclin 1 autophagy related, GT197, VPS30
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Klonalität:
- Polyclonal
- Konjugat:
- ATTO 594
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Beclin 1, the mammalian ortholog of yeast Atg6, is a key regulator of autophagy-a cellular degradation pathway essential for maintaining neuronal homeostasis. As a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex, Beclin 1 orchestrates autophagosome formation and maturation, processes critical for the clearance of damaged organelles and misfolded proteins. In the nervous system, Beclin 1 plays a pivotal role in neurodevelopment and neuroprotection. Dysregulation of Beclin 1-mediated autophagy has been implicated in a range of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease, where impaired protein clearance contributes to synaptic dysfunction and neuronal loss. Beclin 1 is primarily localized to cytoplasmic structures, including mitochondria, but overexpression studies have also revealed nuclear localization, suggesting additional regulatory roles. Notably, reduced Beclin 1 expression has been observed in the hippocampus of individuals with schizophrenia, linking autophagy deficits to psychiatric disorders. Furthermore, Beclin 1 may contribute to neuroimmune defense. It has been shown to protect against infection by neurovirulent strains of Sindbis virus, highlighting its role in antiviral responses within the central nervous system. Given its multifaceted functions in autophagy, neurodevelopment, and immune defense, Beclin 1 is a promising target for therapeutic strategies aimed at restoring cellular homeostasis in neurodegenerative and neuropsychiatric disorders.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from the C-terminus of human Beclin 1
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Predicted molecular weight at ~51kDa.
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Polyclonal Antibody