ENaC gamma Antibody
Produktgrößen
12 ug
£111,00
SPC-405-12UG
100 ug
£460,00
SPC-405-100UG
Über dieses Produkt
- SKU:
- SPC-405
- Zusätzliche Namen:
- SCNN1G, Epithelial Sodium Channel gamma, Amiloride sensitive epithelial sodium channel gamma subunit, Amiloride sensitive sodium channel subunit gamma, Amiloride-sensitive sodium channel subunit gamma, BESC3, ENaC gamma subunit, ENaCG, ENaCgamma, Epithelial Na(+) channel subunit gamma, Epithelial Na+ channel subunit gamma, Gamma ENaC, Gamma NaCH, Gamma-ENaC, Gamma-NaCH, Nonvoltage gated sodium channel 1 subunit gamma, Nonvoltage-gated sodium channel 1 subunit gamma, PHA 1, PHA1, SCNEG, SCNN 1G, SCNNG_HUMAN, Sodium channel non voltage gated 1 gamma subunit, Sodium channel nonvoltage gated 1 gamma
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The gamma subunit of the epithelial sodium channel (ENaCG Gamma) is a vital component of the heterotrimeric ENaC complex, which regulates sodium ion transport across epithelial surfaces. While ENaCG Gamma is traditionally associated with fluid and electrolyte balance in organs such as the kidney, lung, and colon, its emerging role in the nervous system is gaining attention in neurodegenerative disease research. ENaCG Gamma, in conjunction with the beta subunit, is essential for efficient fluid absorption in distal lung epithelia, particularly under edematous conditions. This functional synergy suggests a broader role in maintaining tissue homeostasis under stress. In the retina, differential expression of ENaC subunits-including ENaCG Gamma-has been observed in models of ocular hypertension, implicating ENaCG Gamma in neuroprotective responses to elevated intraocular pressure, a key risk factor in glaucoma. Recent insights propose that ENaCG Gamma may influence neural cell volume regulation, glial activation, and blood-brain barrier integrity-processes that are disrupted in neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis. Its mechanosensitive properties and role in sodium flux position ENaCG Gamma as a potential modulator of neuroinflammation and ionic imbalance in the central nervous system. As the field of neuroionics expands, ENaCG Gamma is emerging as a promising target for therapeutic development and biomarker discovery in neurodegeneration, bridging epithelial physiology and neural resilience.
- Host:
- Rabbit
- Immunogen:
- Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Amphibian, Hamster, Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~83kDa.
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:https://www.stressmarq.com/products/antibodies/polyclonal-antibodies/enac-gamma-antibody-spc-405/