Erk1/2 Antibody
Produktgrößen
12 ul
SPC-120-12UL
100 ul
SPC-120-100UL
Über dieses Produkt
- SKU:
- SPC-120
- Zusätzliche Namen:
- ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3
- Anwendung:
- Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation-hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.
- Host:
- Rabbit
- Immunogen:
- A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Amphibian, Avian, Bovine, Human, Insect/Arthropod, Mouse, Rat, Sheep
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~44kda (ERK1) and ~42kDa (ERK2).
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:https://www.stressmarq.com/products/antibodies/polyclonal-antibodies/erk1-2-antibody-spc-120/