Alpha Synuclein Antibody (Aggregate-Specific), Clone 2F11: RPE
Produktgrößen
100 ug
£593,00
SMC-617D-RPE-100UG
Über dieses Produkt
- SKU:
- SMC-617D-RPE
- Zusätzliche Namen:
- Alpha Synuclein, A Alpha-Synuclein, SNCA, Snca, SYN, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease familial 1, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4, Lewy body 4, Synuclein-alpha, PD1
- Anwendung:
- Conjugation/Labeling, Dot Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- 2F11
- Klonalität:
- Monoclonal
- Konjugat:
- R-PE
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Alpha-synuclein (SNCA) is a presynaptic neuronal protein abundantly expressed in the brain, particularly within the olfactory bulb, hippocampus, striatum, and thalamus (1,2). Localized to both synaptic terminals and mitochondria, alpha-synuclein plays a critical role in synaptic vesicle regulation and cytoskeletal dynamics through its interaction with tubulin (3), suggesting a potential function as a microtubule-associated protein. It is also essential for cognitive development, with SNCA inactivation linked to deficits in spatial learning and working memory (4). Pathologically, alpha-synuclein aggregates are a defining feature of several neurodegenerative diseases. These fibrillar inclusions constitute the major non-AB Beta component of amyloid plaques in Alzheimer's disease and are the principal constituents of Lewy bodies in Parkinson's disease (PD). In PD, progressive accumulation of alpha-synuclein and ubiquitin-positive inclusions in dopaminergic neurons is closely associated with motor and cognitive decline (5,6). Alpha-synuclein aggregation is not merely a byproduct of disease but a driver of neurotoxicity, mitochondrial dysfunction, and synaptic failure. Its central role in disease pathogenesis has made it a high-priority target for biomarker development and therapeutic intervention. Covered by US patent family US11,098,108B2 (7).
- Host:
- Mouse
- Immunogen:
- Mouse alpha synuclein fibrils
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Spezifität:
- This antibody binds a 3-dimensional fibrillar epitope of alpha synuclein (including AA101-120, AA61-80), present in MSA (Multiple System Atrophy) aggregates in human brain samples. It does not appear to detect PD (Parkinson's disease) or PDLB (Parkinson's disease with Lewy Bodies) aggregate structures in human brain samples. It can, however, bind recombinant human PFFs and mouse PFFs.
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Monoclonal Antibody