Clcn3 Antibody, Clone N258/5
Produktgrößen
12 ug
£111,00
SMC-408-12UG
100 ug
£447,00
SMC-408-100UG
Über dieses Produkt
- SKU:
- SMC-408
- Zusätzliche Namen:
- CIC3, CLC3, CLCN 3, Chloride channel 3, Chloride channel protein 3, Chloride channel, voltage-sensitive 3, Chloride transporter ClC 3, DKFZp564I0463, H(+)/Cl(-) exchange transporter 3, Chloride transporter ClC-3, ClC-3
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- N258/5 (Formerly sold as S258-5)
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- ClC-3 (ClCN3) is a voltage-gated chloride/proton exchanger that plays a critical role in regulating endosomal and synaptic vesicle acidification. By mediating Cl-/H⁺ exchange, ClC-3 contributes to vesicle trafficking, neurotransmitter release, and membrane excitability-key processes in neuronal communication and plasticity. In the brain, ClC-3 is expressed in neurons and glial cells, where it influences synaptic vesicle cycling and endolysosomal function. Dysregulation of ClC-3 has been linked to impaired short-term memory, altered neuronal excitability, and neurodegenerative phenotypes in animal models. Its modulation by protein kinase C suggests a role in activity-dependent signaling pathways. Given its involvement in vesicle dynamics and ion homeostasis, ClC-3 is emerging as a potential target in neurodegenerative disease research, particularly in disorders characterized by synaptic dysfunction and lysosomal impairment.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:https://www.stressmarq.com/products/antibodies/monoclonal-antibodies/clcn3-antibody-smc-408/