DNMT1 Antibody, Clone 60B1220.1: ATTO 594
Produktgrößen
100 ug
£509,00
SMC-200D-A594-100UG
Über dieses Produkt
- SKU:
- SMC-200D-A594
- Zusätzliche Namen:
- DNA Mtase, DNMT, MCMT, DNA methyltransferase 1, AIM, CXXC9, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI
- Anwendung:
- ChIP, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- 60B1220.1
- Klonalität:
- Monoclonal
- Konjugat:
- ATTO 594
- Konzentration:
- 1 mg/ml
- Weitere Details:
- DNMT1 (DNA methyltransferase 1) is the primary enzyme responsible for maintaining DNA methylation patterns during cell division. In the nervous system, DNMT1 regulates gene expression, synaptic plasticity, and neuronal differentiation through epigenetic mechanisms. Aberrant DNMT1 activity has been linked to neurodegenerative diseases, where altered methylation contributes to transcriptional silencing of neuroprotective genes and activation of pathogenic pathways. DNMT1 interacts with key regulatory proteins such as retinoblastoma (Rb), E2F1, and HDAC1, forming complexes that influence chromatin structure and gene repression. Loss of DNMT1 function leads to global hypomethylation, genomic instability, and impaired neuronal survival. Its role in epigenetic remodeling makes DNMT1 a promising target for therapeutic intervention and biomarker discovery in neurodegeneration.
- Host:
- Mouse
- Immunogen:
- Raised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1
- Isotyp:
- IgG1, kappa
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Fish, Human, Mouse
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~180kDa. It will cross-react with mouse DNMT1.
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Monoclonal Antibody