FKBP51 Antibody, Clone Hi51B: APC
Produktgrößen
100 ug
SMC-138D-APC-100UG
Über dieses Produkt
- SKU:
- SMC-138D-APC
- Zusätzliche Namen:
- AIG6, FK506 binding protein 5, FKBP5, FKBP54, HSP90 binding immunophilin, p54, Pplase, Ptg10, Rotamase, T cell FK506 binding protein
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- Hi51B
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Konzentration:
- 1 mg/ml
- Weitere Details:
- FKBP51 (FK506-binding protein 5) is a co-chaperone of the Hsp90 complex and a key regulator of glucocorticoid receptor sensitivity, stress response, and protein folding. In the brain, FKBP51 modulates neuronal plasticity, inflammation, and tau protein stability-factors central to neurodegenerative disease progression. Elevated FKBP51 expression has been observed in Alzheimer's disease and is associated with increased tau aggregation and impaired autophagy. Its role in stress hormone signaling also links FKBP51 to mood disorders and cognitive decline, making it a molecular bridge between chronic stress and neurodegeneration. Targeting FKBP51 offers a novel approach to modulate stress-related neurotoxicity and restore proteostasis in aging and diseased brains.
- Host:
- Mouse
- Immunogen:
- Recombinant human FKBP51 fragment
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Canine, Hamster, Human, Mouse, Rabbit, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects ~51kDa.
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Monoclonal Antibody