CaMKII Antibody, Clone 22B1: ATTO 390
Produktgrößen
100 ug
£482,00
SMC-125D-A390-100UG
Über dieses Produkt
- SKU:
- SMC-125D-A390
- Zusätzliche Namen:
- CaMKII, CaM kinase II, CaM KII, CaMK-II, CamK-II, CAMKII, CaMKii, CamKII, Camkii, camKII, camkII, camkii, CAMKIIalpha, CamKIIalpha, CAMKIId, CDPK1, dCAMKII, dCaMKII, DCK, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKA
- Anwendung:
- ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- translate.label.attr.clone:
- 22B1
- Klonalität:
- Monoclonal
- Konjugat:
- ATTO 390
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal serine/threonine kinase that plays a critical role in synaptic plasticity, memory formation, and neurodegenerative disease mechanisms. Highly enriched in forebrain neurons, CaMKII is localized to both the soma and dendrites, where it orchestrates calcium signaling in response to synaptic activity. The neuronal isoforms-comprising 52 kDa (A Alpha subunit) and 60 kDa (B Beta subunit)-assemble into multimeric holoenzymes that integrate calcium dynamics with downstream signaling. CaMKII activation is initiated by Ca²⁺/calmodulin binding, which relieves autoinhibition and triggers autophosphorylation at threonine 286 (Thr286). This phosphorylation event confers autonomous kinase activity, even after calcium levels subside, and enhances CaMKII's affinity for NMDA receptors at postsynaptic densities-an essential mechanism for long-term potentiation (LTP). The phosphorylation state of Thr286 is tightly regulated: protein phosphatase 1 (PP1) dephosphorylates it, while protein kinase A (PKA) counteracts this dephosphorylation, sustaining CaMKII activity. Dysregulation of CaMKII signaling has been implicated in multiple neurodegenerative disorders, including Alzheimer's disease, where aberrant phosphorylation and synaptic dysfunction are hallmark features. As a master regulator of synaptic strength and plasticity, CaMKII remains a high-value target in neuroscience research and therapeutic development for cognitive and neurodegenerative disorders.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide to Rat CaMKII
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Detects phosphorylated CaMKII from rat tissues. This antibody is specific for A Alpha and B Beta subunits of CaMKII only when they are phosphorylated at Thr-286/287 (in B Beta).
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Typ:
- Antibody: Monoclonal Antibody