Alpha Synuclein Oligomer ELISA Kit
Produktgrößen
96 wells
£532,00
SKT-143-96WELLS
Über dieses Produkt
- SKU:
- SKT-143
- Zusätzliche Namen:
- A Alpha syn oligomers, aSyn oligomers, prefibrillar A Alpha syn aggregates, alpha synuclein, A Alpha syn, aSyn, SNCA, Non A4 / Non AB Beta Component of AD Amyloid, NACP, PARK1, PARK4
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Weitere Details:
- Alpha synuclein oligomers represent a soluble, neurotoxic form of the presynaptic protein and are increasingly recognized as early drivers of pathology in neurodegenerative disease. These oligomeric species disrupt synaptic vesicle trafficking and neurotransmission, impairing presynaptic function well before the formation of mature fibrillar aggregates. Localized effects extend to mitochondria, where oligomers induce oxidative stress, lysosomal dysfunction, and endoplasmic reticulum stress, contributing to neuronal vulnerability in Parkinson's disease (PD) and related synucleinopathies. Their capacity to propagate in a prion like manner and initiate early synaptic and inflammatory disturbances underscores their importance in disease progression and positions them as high value targets for biomarker development and therapeutic intervention. StressMarq's Alpha Synuclein Oligomer ELISA has demonstrated higher affinity to oligomers than to PFFs or monomers.
- Format:
- Colorimetric
- Immunogen:
- Alpha Synuclein Oligomer ELISA Kit
- Physischer Zustand:
- Tissue Homogenate
- Reichweite:
- 15.6 - 1,000 pg/mL
- Reaktivitäten:
- Human, Mouse
- Empfindlichkeit:
- 10 pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C, -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:https://www.stressmarq.com/products/assay-kits/elisa-kits/alpha-synuclein-oligomer-elisa-kit-skt-143/