Dyclonine HCl
Produktgrößen
100 mg
£103,00
SIH-638-100MG
1 g
£153,00
SIH-638-1G
Über dieses Produkt
- SKU:
- SIH-638
- Zusätzliche Namen:
- 4'-Butoxy-3-piperidinopropiophenone, hydrochloride; dyclocaine
- CAS Number:
- 536-43-6
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Weitere Details:
- This topical anesthetic, traditionally used for oral and pharyngeal analgesia¹, also exhibits several mechanisms relevant to neuronal health. It enhances mitochondrial function in neurons, increasing respiratory capacity and providing protection against stressors associated with neurodegenerative disorders². The compound inhibits the aldehyde dehydrogenase isoform ALDH3A1, leading to the accumulation of 4-hydroxynonenal; in cancer models, this sensitizes head and neck squamous cell carcinoma cells to the cystine-glutamate antiporter inhibitor sulfasalazine³. Notably, it rescues frataxin deficiency in animal models and in buccal cells from patients with Friedreich's ataxia⁴, suggesting therapeutic potential in mitochondrial neurodegeneration. In cancer cells, it also enhances the cytotoxicity of the proteasome inhibitors MG-132⁵ and bortezomib⁶.
- Molekulargewicht:
- 325.9
- Reinheit:
- >98%
- Versandbedingungen:
- Ambient
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Datenblatt des Herstellers:https://www.stressmarq.com/products/small-molecules/inhibitor/dyclonine-hcl-sih-638/