4-Octyl itaconate
Produktgrößen
10 mg
£120,00
SIH-637-10MG
50 mg
£180,00
SIH-637-50MG
Über dieses Produkt
- SKU:
- SIH-637
- Zusätzliche Namen:
- 4-Octyl methylenesuccinate; or n-Octyl 3-carboxy-3-butenoate
- CAS Number:
- 3133-16-2
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Weitere Details:
- 4-Octyl itaconate is a cell-permeable derivative of itaconic acid that activates the neuroprotective transcription factor Nrf2 through alkylation of KEAP1¹. In neural systems, Nrf2 activation is closely associated with antioxidant defense and suppression of neuroinflammatory signaling. 4-Octyl itaconate inhibits several regulated cell-death pathways relevant to neurological disease, including ferroptosis²-a major contributor to neuronal and glial oxidative injury-as well as gasdermin B-mediated pyroptosis³, a key driver of neuroinflammatory cytokine release. In addition, it enhances secretion of anti-inflammatory mediators⁴ and promotes a wound-resolving, pro-repair phenotype in activated macrophages⁵, suggesting potential to shift microglia and infiltrating myeloid cells toward a neuroprotective state in models of neurodegeneration or CNS injury.
- Molekulargewicht:
- 242.3
- Reinheit:
- >98%
- Versandbedingungen:
- Ambient
- Quelle:
- Snythetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Datenblatt des Herstellers:https://www.stressmarq.com/products/small-molecules/inhibitor/4-octyl-itaconate-sih-637/