Epoxomicin
Produktgrößen
100 ug
SIH-388-100UG
Über dieses Produkt
- SKU:
- SIH-388
- Zusätzliche Namen:
- N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide
- CAS Number:
- 134381-21-8
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Weitere Details:
- Epoxomicin is a potent, cell-permeable, and selective inhibitor of the proteasome, originally isolated from an Actinomycetes strain for its antitumor properties. In neuroscience, Epoxomicin is widely used to study the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and cellular homeostasis in neurons. Dysfunction of the UPS is a hallmark of several neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease, where misfolded or aggregated proteins accumulate. Epoxomicin inhibits the chymotrypsin-like, trypsin-like, and PGPH activities of the proteasome, making it a valuable tool for dissecting proteostasis mechanisms. It also indirectly activates autophagy, a compensatory degradation pathway, by blocking UPS function. Additionally, Epoxomicin suppresses NF-K KappaB activation and inflammation, further supporting its use in neuroinflammatory models. Its dual role in modulating protein clearance and inflammatory signaling makes it highly relevant in neurodegenerative disease research.
- Molekulargewicht:
- 554.7
- Reinheit:
- >95%
- Versandbedingungen:
- Ambient
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Datenblatt des Herstellers:https://www.stressmarq.com/products/small-molecules/inhibitor/epoxomicin-sih-388/