NGFR/p75 neurotrophin receptor (p75NTR), Mouse Monoclonal Antibody (Saporin)
Produktgrößen
25 ug
£382,00
M-1755IT-25UG
50 ug
£692,00
M-1755IT-50UG
100 ug
£1112,00
M-1755IT-100UG
Über dieses Produkt
- SKU:
- M-1755IT
- Zusätzliche Namen:
- Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271
- Anwendung:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MC192
- Klonalität:
- Monoclonal
- Konjugat:
- Saporin
- Weitere Details:
- MC192-saporin is an antibody conjugate comprising of the monoclonal antibody MC192 against rat p75NTR, the nerve growth factor receptor, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Unconjugated saporin is incapable of entering the cells due to the apparent lack of ligand. Upon specific binding via MC192 to the cells expressing p75NTR, saporin transverses the cell membrane leading to lesion of neurochemically defined neuronal populations. The targets of MC192-Saporin are p75NTR-expressing cells including cholinergic neurons of the basal forebrain, cerebellar Purkinje cells, medial septum, diagonal band of Broca, Nucleus basalis of Meynert and some tumour cells. MC192-saporin has been used in the study of learning and memory and its primary application is in vivo, MC192-saporin is specific for applications in rat. The antibody does not cross-react with human or mouse p75NTR receptors.
- Format:
- Lyophilized from a 1 mg/mL solution containing PBS pH 7.2-7.6 without preservative.
- Host:
- Mouse
- Immunogen:
- Rat NGF receptor (p75NTR)
- Isotyp:
- IgG1
- Aufreinigung:
- Ion Exchange
- Reaktivitäten:
- Rat
- Versandbedingungen:
- Ambient
- Spezifität:
- MC192 antibody is specific only for rat NGFR, no reactivity to human or mouse NGFR has been reported This monoclonal antibody does not cross react with p75NTR-expressing cells in other species than rat.
- Lagerbedingungen:
- 2-8[o]C reconstituted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Biosensis
- Typ:
- Antibody: Monoclonal Antibody