CD31/PECAM-1, soluble
Produktgrößen
10ug
£147,06
S01-071S-10UG
Über dieses Produkt
- SKU:
- S01-071S
- Zusätzliche Namen:
- PECAM-1; CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
- Weitere Details:
- DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.
- Formulierung:
- lyophilized
- Host:
- E. coli
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Room Temperature