VEGFR-1/Flt-1, Agonistic
Produktgrößen
100 ug
£976,47
mV1004m-h-100UG
Über dieses Produkt
- SKU:
- mV1004m-h
- Zusätzliche Namen:
- vascular endothelial growth factor receptor-1; FLT1; FLT; VEGF receptor 1
- Anwendung:
- Stimulation, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 8F12
- Klonalität:
- Monoclonal
- Weitere Details:
- Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVEC supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- hVEGFR1 N-terminal fragment (N25-250)
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody