Midkine / MDK Protein
Produktgrößen
50 ug
£494,00
600-182-L50-50UG
Über dieses Produkt
- SKU:
- 600-182-L50
- Zusätzliche Namen:
- ARAP Protein; FLJ27379 Protein; MK Protein; MK1 Protein; NEGF2 Protein
- Buffer:
- 50mM PBS, 1 M NaCl, pH 6.8
- Weitere Details:
- Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase and the induction of cell proliferation. Midkine is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Midkine exhibited increased expression in the breast carcinomas but showed much lower expression in the normal breast tissue. Thus, it can be used as a breast carcinomas marker.
- Formulierung:
- lyophilized or frozen liquid
- Molekulargewicht:
- 18 kDa
- Reinheit:
- >95%
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins