ALK5
Produktgrößen
100 ug
£674,12
103-M96-100UG
Über dieses Produkt
- SKU:
- 103-M96
- Zusätzliche Namen:
- Tgfbr1; ALK5; Alk-5; TbetaRI; AU017191; TbetaR-I
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3A11
- Klonalität:
- Monoclonal
- Weitere Details:
- Most cell types express three sizes of receptors for TGFB Beta. These are designated Type I (53 kDa), Type II (7085 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membranebound and soluble forms, binds TGFB Beta1, TGFB Beta2, and TGFB Beta3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane bound serine/threonine kinase that binds TGFB Beta1 and TGFB Beta3 with high affinity and TGFB Beta2 with a much lower affinity. The Type I receptor, originally known as ALK5 (Activin receptor-like kinase) is also a membranebound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGFB Beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recmobinant mouse ALK5 extracellular domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody