PDGFR-beta
Produktgrößen
100 ug
£674,12
103-M44-100UG
Über dieses Produkt
- SKU:
- 103-M44
- Zusätzliche Namen:
- Pdgfrb; Pdgfr; CD140b; PDGFR-1; AI528809
- Anwendung:
- IHC-Paraffin, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 4C54
- Klonalität:
- Monoclonal
- Weitere Details:
- The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, B, C, and D) that form disulfidelinked homodimers (PDGF-AA, BB, CC, and DD) and a heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or heterodimerization of two receptors (PDGF RA Alpha and RB Beta). Whereas A Alpha/A Alpha homodimerization is induced by PDGF-AA, BB, CC, and AB, A Alpha/B Beta heterodimerization is induced by PDGF-AB, -BB, CC, and DD, and B Beta/B Beta homodimerization is induced only by PDGF-BB, and DD. Both PDGF-RA Alpha and -RB Beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for MCSF, SCF and Flt3-ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the A Alpha and B Beta receptors. Others have only the A Alpha receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets and megakaryocytes) or only the B Beta receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells and macrophages). A soluble PDGF RA Alpha has been detected in normal human plasma and serum as well as in the conditioned medium of the human osteosarcoma cell line MG63. Both the recombinant mouse and human soluble PDGF RA Alpha bind PDGF with high affinity and are potent PDGF antagonists.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse PDGFR beta extracellular domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody