PDGFR-alpha
Produktgrößen
100 ug
£674,12
103-M43-100UG
Über dieses Produkt
- SKU:
- 103-M43
- Zusätzliche Namen:
- Pdgfra; CD140a; Pdgfr-2; AI115593
- Anwendung:
- IHC-Paraffin, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3G28
- Klonalität:
- Monoclonal
- Weitere Details:
- The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGFA, B, C, and D) that form disulfide-linked homodimers (PDGFAA, BB, CC, and DD) and a heterodimer (PDGFAB). These proteins regulate diverse cellular functions by binding to and inducing the homoor heterodimerization of two receptors (PDGF RA Alpha and RB Beta). Whereas A Alpha/A Alpha homodimerization is induced by PDGF-AA, BB, CC, and AB, A Alpha/B Beta heterodimerization is induced by PDGF-AB, BB, CC, and DD, and B Beta/B Beta homodimerization is induced only by PDGF-BB and DD. Both PDGF RA Alpha and RB Beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for MCSF, SCF, and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulinlike domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-iinduced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the A Alpha and B Beta receptors. Others have only the A Alpha receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets, and megakaryocytes) or only the B Beta receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells, and macrophages). Recombinant mouse and human soluble PDGF RB Beta bind PDGF with high affinity and are potent PDGF antagonists.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse PDGFR alpha extracellular domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody