IL-21
Produktgrößen
100 ug
£674,12
103-M416-100UG
Über dieses Produkt
- SKU:
- 103-M416
- Zusätzliche Namen:
- Il21
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6G53
- Klonalität:
- Monoclonal
- Weitere Details:
- IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse IL-21
- Isotyp:
- IgG2
- Aufreinigung:
- Protein A/G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody