CCL-19
Produktgrößen
100 ug
£674,12
103-M324-100UG
Über dieses Produkt
- SKU:
- 103-M324
- Zusätzliche Namen:
- Ccl19; ELC; CKb11; MIP3B; Scya19; exodus-3
- Anwendung:
- Block/Inhibit/Neutralise, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 10J38
- Klonalität:
- Monoclonal
- Weitere Details:
- CCL19/MIP3B Beta, also known as ELC (EBI1Ligand Chemokine), is a B Beta chemokine that binds specifically to the chemokine receptor CCR7/EBI1/ BLR2. Mouse (human) CCL19 cDNA encodes a 108 (98) amino acid precursor protein with a predicted 25 (21) aa signal peptide that is cleaved to form the 83 (77) aa mature secreted protein. CCL19 is distantly related to other B Beta chemokines (20-30% aa sequence identity). Mouse CCL19 shares 83% aa sequence homology with human CCL19. CCL19 has been shown to be constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix, and spleen) in dendritic cells within the T-cell zone. The expression of CCL19 is downregulated by the antiinflammatory cytokine IL10. Recombinant CCL19 has been shown to be chemotactic for Tcells and Bcells. The CCL19 receptor (CCR7/ EBI1/ BLR2) is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is also strongly upregulated in Bcells infected with EpsteinBarr virus and T-cells infected with herpesvirus 6 or 7.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse CCL-19
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G/A chromatography
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody