TIMP-1
Produktgrößen
100 ug
£674,12
103-M277-100UG
Über dieses Produkt
- SKU:
- 103-M277
- Zusätzliche Namen:
- Timp1; Clgi; Timp; TIMP-1
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6A34
- Klonalität:
- Monoclonal
- Weitere Details:
- TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- mouse recombinant TIMP-1 protein
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody