ADAM-9
Produktgrößen
100 ug
£674,12
103-M213-100UG
Über dieses Produkt
- SKU:
- 103-M213
- Zusätzliche Namen:
- Adam9; MDC9; Mltng; AU020942; mKIAA0021
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7D10
- Klonalität:
- Monoclonal
- Weitere Details:
- ADAM9, also known as MDC9 or meltrin G Gamma, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factorA Alpha (TNFA Alpha), the p75 TNF receptor, the B Beta-amyloid protein precursor, and the c-kit ligand1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B-chain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molelcule through binding of its disintegrin domain to integrins such as A AlphavB Beta5 and A Alpha6B Beta1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.
- Formulierung:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse ADAM-9 (extracellular domain)
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody