TNF-alpha
Produktgrößen
100 ug
£365,88
102-P87G-100UG
Über dieses Produkt
- SKU:
- 102-P87G
- Zusätzliche Namen:
- TNF; DIF; TNFA; TNFSF2; TNF-alpha
- Anwendung:
- Block/Inhibit/Neutralise, ELISA, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- Tumor necrosis factor alpha (TNF-A Alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-A Alpha is produced by a wide variety of immune and epithelial cell types. Human TNF-A Alpha consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-A Alpha shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-A Alpha. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.
- Formulierung:
- lyophilized from PBS
- Host:
- Goat
- Immunogen:
- recombinant human TNF-alpha
- Aufreinigung:
- Antigen-affinity purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Polyclonal Antibody