IL-18 (IL-1F4)
Produktgrößen
100 ug
£674,12
101-M784-100UG
Über dieses Produkt
- SKU:
- 101-M784
- Zusätzliche Namen:
- Interleukin-18, Iboctadekin, Interferon gamma-inducing factor, (IFN-gamma-inducing factor), Interleukin-1 gamma (IL-1 gamma)
- Buffer:
- PBS
- translate.label.attr.clone:
- 42U51
- Klonalität:
- Monoclonal
- Weitere Details:
- Interleukin-18 (IL-18) is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma D DeltaT cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases. IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Recombinant human IL-18 (IL-1F4)
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody