GDF-15
Produktgrößen
100 ug
£674,12
101-M755-100UG
Über dieses Produkt
- SKU:
- 101-M755
- Zusätzliche Namen:
- GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
- Anwendung:
- Immunocytochemistry
- Buffer:
- PBS
- translate.label.attr.clone:
- 10A43
- Klonalität:
- Monoclonal
- Weitere Details:
- GDF-15 belongs to the TGF-B Beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human GDF-15
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody