MD-1
Produktgrößen
100 ug
£674,12
101-M566-100UG
Über dieses Produkt
- SKU:
- 101-M566
- Zusätzliche Namen:
- LY86; MD-1; MMD-1; dJ80N2.1; RP1-80N2.1
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 1X55
- Klonalität:
- Monoclonal
- Weitere Details:
- MD1 is a secreted glycoprotein that is associated with RP105 and is required for efficient RP105 cell surface expression and function. RP105 is a type I transmembrane glycoprotein with extracellular leucine rich repeats (LRR) typically found in Toll-like receptor (TLR) family members. However, RP105 has a short cytoplasmic tail and lacks the Toll-IL1 R (TIR) domain that defines the IL1 R/TLR superfamily. RP105 plays an important role in B-cell activation by bacterial lipopolysaccharide (LPS). It is expressed primarily on mature B cells, dendritic cells and macrophages. Human MD1 cDNA encodes a 162 amino acid (aa) precursor protein with a putative 19 aa signal peptide and two potential N-linked glycosylation sites. It shares 38% and 66% amino acid sequence identity with chicken and mouse MD1 respectively. MD1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney. The cell surface RP105/MD 1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in B cells. Activation of the RP105 complex has been shown to protect against apoptosis, induce B-cell proliferation and upregulate B7.2, a costimulatory molecule. Since MD1 is also expressed in liver and brain where RP105 is absent, MD1 may also be associated with other LRR-containing molecules, or have additional functions outside the immune system.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human MD-1
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody