LAP/ TGF beta 1
Produktgrößen
100 ug
£674,12
101-M546-100UG
Über dieses Produkt
- SKU:
- 101-M546
- Zusätzliche Namen:
- TGFB1; CED; LAP; DPD1; TGFB; TGFbeta
- Anwendung:
- Block/Inhibit/Neutralise, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6G14
- Klonalität:
- Monoclonal
- Weitere Details:
- TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human LAP TGF beta1
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody