IL-13 receptor alpha
Produktgrößen
100 ug
£674,12
101-M478-100UG
Über dieses Produkt
- SKU:
- 101-M478
- Zusätzliche Namen:
- IL13RA1; NR4; CD213A1; IL-13Ra
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 10A51
- Klonalität:
- Monoclonal
- Weitere Details:
- Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human IL-13R alpha 1 EC domain
- Isotyp:
- IgG2
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody