CD86
Produktgrößen
100 ug
£674,12
101-M317-100UG
Über dieses Produkt
- SKU:
- 101-M317
- Zusätzliche Namen:
- B7-2; B70; Ly-58
- Anwendung:
- Block/Inhibit/Neutralise, Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7F35
- Klonalität:
- Monoclonal
- Weitere Details:
- B7-1 and B7-2 (CD86), together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B72 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant CD86 EC domian
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody