ACE
Produktgrößen
100 ug
£674,12
101-M200-100UG
Über dieses Produkt
- SKU:
- 101-M200
- Zusätzliche Namen:
- Angiotensin I converting enzyme; CD143; testicular ECA carboxycathepsin; DCP; ACE1; DCP1; MVCD3
- Anwendung:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 12J16
- Klonalität:
- Monoclonal
- Weitere Details:
- Angiotensin I Converting Enzyme (ACE, also known as peptidyl-dipeptidase A, kininase II, or CD143) is a type I transmembrane zinc metallopeptidase that is important in the metabolism of the vaso-active peptides angiotensin II and bradykinin. Two isoforms of ACE that exhibit distinct physiologic functions have been described: germinally expressed ACE (gACE) and somatic cell expressed ACE (sACE). Both isoforms are transcribed from a single gene using alternative promoters. The gACE isoform is exclusively expressed in the testes, whereas sACE is expressed on endothelial cells, epithelial cells, neuronal cells, and dendritic cells. A soluble form of CD143 is likely shed from endothelial cells and is found in serum, plasma, seminal fluid, amniotic fluid and cerebral spinal fluid. Functionally, CD143 has a role in blood pressure regulation, electrolyte balance, reproduction, cardiovascular disease, kidney disease, cancer and Alzheimer's disease. Inhibitors of ACE are used clinically to treat hypertension, cardiac failure, and diabetic retinopathy.
- Formulierung:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human ACE recombinant protein (extracellular domain)
- Isotyp:
- IgG1
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Typ:
- Antibody: Monoclonal Antibody