anti-Major vault protein (MVP), 1032, mouse monoclonal antibody
Produktgrößen
100 ug
£432,00
691525-100UG
Über dieses Produkt
- SKU:
- 691525
- Zusätzliche Namen:
- Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
- Anwendung:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 1032
- Klonalität:
- Monoclonal
- Konzentration:
- 100 ug/ml
- Weitere Details:
- 1032 is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Positive control: MCF-7 or HeLa cells, breast cancer.
- Formulierung:
- PBS with 0.02% sodium azide
- Host:
- Mouse
- Immunogen:
- Affinity purified nuclear extract proteins
- Isotyp:
- IgG1, kappa
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Please refer to datasheet
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:691525
